The current issued share capital of the company consists of 192,172,408 Ordinary shares of 1p each.

• Cubana Investments Ltd
  12th August 2011

• Sanofi-Aventis
  23rd November 2010

• Sanofi-Aventis
  14th October 2010

• Sanofi-Aventis
  21st July 2010

• Cubana Investments Ltd
  1st July 2010

• Sanofi-Aventis
  4th June 2010

• Cubana Investments Ltd
  1st February 2010

• Sanofi-Aventis
  13th November 2009

• Cubana Investments Ltd
  16th July 2009

• Sanofi-Aventis
  5th May 2009

• Cubana Investments Ltd
  20th March 2009

• Sanofi-Aventis
  18th March 2009

• Sanofi-Aventis
  25th February 2009

• Total Voting Rights
  31st October 2008

• Credit Agricole
  20th October 2008

• Cubana Investments Ltd
  13th October 2008

• Cubana Investments Ltd
  5th August 2008

• Deutsche Bank AG
  21st July 2008

• Deutsche Bank AG
  2nd July 2008

• Deutsche Bank AG
  19th May 2008

• Total Voting Rights
  17th April 2008

• Directors' Shareholdings
  10th April 2008

• Issue of Equity, Directors' Dealings and Total Voting Rights
  10th April 2008

• Cubana Investments plc
  1st April 2008

• Cubana Investments plc
  13th March 2008

• Deutsche Bank AG
  13th March 2008

• MF Global
  19th February 2008

• MF Global
  15th February 2008

• Cubana Investments Limited
  14th February 2008

• MF Global
  13th February 2008

• MF Global
  22nd January 2008

• MF Global
  18th January 2008

• Credit Agricole
  20th November 2007

• Credit Agricole
  20th November 2007

• MF Global
  19th November 2007

• MF Global
  5th November 2007

• MF Global
  9th October 2007

• MF Global
  6th September 2007

• Directors Dealings
  25th July 2007

• Sanofi-Aventis
  12th July 2007

• Fidelity
  6th July 2007

• LTIP Awards
  2nd July 2007

• Sanofi-Aventis
  22nd May 2007

• Credit Agricole Cheuvreux International Ltd
  14th May 2007

• Fidelity International Ltd
  10th May 2007

• Extension of Option Exercise Period
  20th April 2007

• Credit Agricole Cheuvreux International Ltd
  19th April 2007

• Credit Agricole Cheuvreux International Ltd
  13th April 2007

• Credit Agricole Cheuvreux International Ltd
  13th April 2007

• FMR Corp Financial
  20th March 2007

• Fidelity International Ltd
  20th March 2007

• Credit Agricole Cheuvreux International Ltd
  19th March 2007

• Man Financial
  19th February 2007

• Man Financial Ltd
  5th January 2007

• Sanofi-Aventis
  21st December 2006

• Total Voting Rights
  13th December 2006

• Man Financial
  31st October 2006

• Fidelity
  27th July 2006

• Man Financial
  20th May 2006

• Credit Agricole
  20th May 2006

• Fidelity
  7th April 2006

• Fidelity
  22nd February 2006