SIX MONTHS TO 26TH OCTOBER, 2009

26th October 2009

a. Proteome Sciences plc

b. Approved Share Option Scheme

Unapproved Share Option Scheme (No. 2)

2004 Share Option Plan

c. 26th April, 2009 to 26th October, 2009

d. 648,596 Ordinary shares of 1p each

e. - Ordinary shares of 1p each

f. 648,596 Ordinary shares of 1p each

g. 1,000,000 Ordinary shares of 1p each - 26th October, 2004

h. James Malthouse – 01932 865065